Citrate, in the form of potassium citrate, has been used to resupply patients who have low urinary levels of citrate in an effort to limit calcium crystallization. Specifically, potassium citrate forms a soluble complex with calcium reducing the amount for binding with oxalate. Or more simply put, citrate stabilizes the urinary environment.
- Pak CYC, et al. Long Term Treatment of Calcium Nephrolithiasis with Potassium Citrate. The Journal of Urology: 134:11-19.
- Lee YH, Huang WC. The efficacy of potassium citrate based medical prophylaxis for preventing upper urinary tract calculi; a midterm follow up study. The Journal of Urology 1999;161:1453-7.